Identification of a novel pathway and its therapeutic target of tobacco promotion of lung cancer

Lung cancer is the main cause of cancer death in the world ,causing about 1,2 million deaths annually and 90%of lung cancer are related to tobacco smoking .The objectives of this project are to identify the molecular pathway that nicotine undergoes in lung cancer cells and to find a method of inhibiting the effects of of nicotine .The hypothesis is that nicotine in tobacco stimulates pathological lung tumor progression and metastasis through a moesin-RhoA mediated novel signal pathway. targeting components in the novel therapeutic approaches to the treatment of lung cancers.